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Ebola vaccine trial proves 100% successful in Guinea
Welker radio_button_checked
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#1
Aug 1, 2015, 02:04 PM
To test how well the vaccine protected people, the cluster outbreaks were randomly assigned either to receive the vaccine immediately or three weeks after Ebola was confirmed. Among the 2,014 people vaccinated immediately, there were no cases of Ebola from 10 days after vaccination – allowing time for immunity to develop – according to the results published online in the Lancet medical journal. In the clusters with delayed vaccination, there were 16 cases out of 2,380.

In another precedent-breaker, the trial was sponsored by the World Health Organisation because “nobody wanted to step into this role so we took the risk”, said assistant director-general, Dr Marie-Paule Kieny.

Funding came from the Wellcome Trust and other partners, including the governments of Norway and Canada. Others involved included Médecins sans Frontières, whose volunteer doctors were on the front line, and the London School of Hygiene and Tropical Medicine. About 90% of the trial staff were from Guinea, a country where no clinical research had been carried out before. The vaccine is made by Merck.

Kieny said: “We believe that the world is on the verge of an efficacious Ebola vaccine.”

The trial will continue, but without randomisation, which means that in Guinea, where there have been 3,786 cases and 2,520 confirmed deaths, every contact of a person who develops Ebola – and their contacts – will be offered it. Work in Gabon has now established that the vaccine is safe for children and adolescents, so they will be offered it, too.


Ebola in Sierra Leone: 'Remind people not to forget about us, the survivors'

In terms of vaccines, which are usually trialled in hundreds of thousands of people, Kierny said the numbers were small but highly promising. It is likely when larger numbers are collected that efficacy will be between 75% and 100%.

The future of two other potential Ebola vaccines, one from GlaxoSmithKline and the other from Johnson & Johnson, is now in question, because there are too few cases of Ebola for their trials to be completed.

The authors of the research said the ring design made it “logistically feasible” to conduct trials even in poor countries in the middle of a fading epidemic and it was a promising strategy for the future.

“This trial dared to use a highly innovative and pragmatic design, which allowed the team in Guinea to assess this vaccine in the middle of an epidemic,” said Jeremy Farrar, director of the Wellcome Trust and one of the world’s leading experts on infectious disease. “It is a remarkable result which shows the power of equitable international partnerships and flexibility.

“Our hope is that this vaccine will now help bring this epidemic to an end and be available for the inevitable future Ebola epidemics. This partnership also shows that such critical work is possible in the midst of a terrible epidemic. It should change how the world responds to such emerging infectious disease threats.”


UN special envoy says Ebola flare-ups could continue for some time

John-Arne Røttingen, the head of infectious disease control at the Norwegian Institute of Public Health and chair of the trial’s steering group, said it had been a race against time in the most challenging circumstances.

“We are really pleased with the interim results,” he said. “It is really important to add the vaccine to the traditional hygiene measures we have used in the response so far. I believe this will be an important contribution to getting down to zero cases.”

Médecins sans Frontières said it was keen for the vaccine to be used in Sierra Leone and Liberia, where there were still cases.

Bertrand Draguez, MSF’s medical director, said: “In parallel with the ring vaccination we are also conducting a trial of the same vaccine on front-line workers. These people have worked tirelessly and put their lives at risk every day to take care of sick people. If the vaccine is effective, then we are already protecting them from the virus.

“With such high efficacy, all affected countries should immediately start and multiply ring vaccinations to break chains of transmission and vaccinate all front-line workers to protect them.”


WHO incapable of reacting to crises such as Ebola, says report

Margaret Chan, the director general of of the WHO, said the vaccine trial’s success was a promising development. “The credit goes to the Guinean government, the people living in the communities and our partners in this project.”

The British government contributed £1m of the trial funding and has said it will increase that amount to help allow the testing to continue.

“Ebola has claimed thousands of lives and devastated communities across west Africa,” the international development secretary, Justine Greening, said. “The results of these UK-backed vaccine trials are hugely promising and represent a significant breakthrough in our battle against this deadly disease. The vaccine offers hope for a future where we never have to face an Ebola epidemic like this again.”

Trial data will now go to regulatory agencies in the hope of getting a licence for the vaccine that will allow it to be stockpiled for future Ebola epidemics. It is likely to be used only for people at risk in outbreaks and not given to whole populations.

The rVSV-ZEBOV vaccine is sometimes known as the Canadian vaccine as it was originally developed by the Public Health Agency of Canada before being sold to Merck to conclude the testing.



I've never done a news thread but it was empty and it looked lonely.. ???
Safira radio_button_checked
birds arent real
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#2
Aug 1, 2015, 02:06 PM
You posted 13 seconds before me...

Great minds think alike! Or in your case, it was just coincidental. You're not as smart as me. :p
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Welker radio_button_checked
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#3
Aug 1, 2015, 02:08 PM
(Aug 1, 2015, 02:06 PM)Safira link Wrote: You posted 13 seconds before me...

Great minds think alike! Or in your case, it was just coincidental. You're not as smart as me. :p

You're right! I'm smarter!
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#4
Aug 1, 2015, 04:08 PM
Woo hoo, good job people!
Dig radio_button_checked
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#5
Aug 1, 2015, 04:29 PM
Woop woop!
1 When the heavens above did not exist,
2 And earth beneath had not come into being —
3 There was Apsû, the first in order, their begetter,
4 And demiurge Tia-mat, who gave birth to them all;
5 They had mingled their waters together
6 Before meadow-land had coalesced and reed-bed was to he found —
7 When not one of the gods had been formed
8 Or had come into being, when no destinies had been decreed,
9 The gods were created within them:
10 Lah(mu and Lah(amu were formed and came into being.
11 While they grew and increased in stature
12 Anšar and Kišar, who excelled them, were created.
13 They prolonged their days, they multiplied their years.
14 Anu, their son, could rival his fathers.
15 Anu, the son, equalled Anšar,
16 And Anu begat Nudimmud, his own equal.
17 Nudimmud was the champion among his fathers:
18 Profoundly discerning, wise, of robust strength;
19 Very much stronger than his father's begetter, Anšar
20 He had no rival among the gods, his brothers.
21 The divine brothers came together,
22 Their clamour got loud, throwing Tia-mat into a turmoil.
23 They jarred the nerves of Tia-mat,
24 And by their dancing they spread alarm in Anduruna.
25 Apsû did not diminish their clamour,
26 And Tia-mat was silent when confronted with them.
27 Their conduct was displeasing to her,
28 Yet though their behaviour was not good, she wished to spare them.
29 Thereupon Apsû, the begetter of the great gods,
30 Called Mummu, his vizier, and addressed him,
31 "Vizier Mummu, who gratifies my pleasure,
32 Come, let us go to Tia-mat!"
33 They went and sat, facing Tia-mat,
34 As they conferred about the gods, their sons.
35 Apsû opened his mouth
36 And addressed Tia-mat
37 "Their behaviour has become displeasing to me
38 And I cannot rest in the day-time or sleep at night.
39 I will destroy and break up their way of life
40 That silence may reign and we may sleep."
41 When Tia-mat heard this
42 She raged and cried out to her spouse,
43 She cried in distress, fuming within herself,
44 She grieved over the (plotted) evil,
45 "How can we destroy what we have given birth to?
46 Though their behaviour causes distress, let us tighten discipline graciously."
47 Mummu spoke up with counsel for Apsû—
48 (As from) a rebellious vizier was the counsel of his Mummu—
49 "Destroy, my father, that lawless way of life,
50 That you may rest in the day-time and sleep by night!"
51 Apsû was pleased with him, his face beamed
52 Because he had plotted evil against the gods, his sons.
53 Mummu put his arms around Apsû's neck,
54 He sat on his knees kissing him.
55 What they plotted in their gathering
56 Was reported to the gods, their sons.
57 The gods heard it and were frantic.
58 They were overcome with silence and sat quietly.
59 Ea, who excels in knowledge, the skilled and learned,
60 Ea, who knows everything, perceived their tricks.
61 He fashioned it and made it to be all-embracing,
62 He executed it skilfully as supreme—his pure incantation.
63 He recited it and set it on the waters,
64 He poured sleep upon him as he was slumbering deeply.
65 He put Apsû to slumber as he poured out sleep,
66 And Mummu, the counsellor, was breathless with agitation.
67 He split (Apsû's) sinews, ripped off his crown,
68 Carried away his aura and put it on himself.
69 He bound Apsû and killed him;
70 Mummu he confined and handled roughly.
71 He set his dwelling upon Apsû,
72 And laid hold on Mummu, keeping the nose-rope in his hand.
73 After Ea had bound and slain his enemies,
74 Had achieved victory over his foes,
75 He rested quietly in his chamber,
76 He called it Apsû, whose shrines he appointed.
77 Then he founded his living-quarters within it,
78 And Ea and Damkina, his wife, sat in splendour.
79 In the chamber of the destinies, the room of the archetypes,
80 The wisest of the wise, the sage of the gods, Be-l was conceived.
81 In Apsû was Marduk born,
82 In pure Apsû was Marduk born.
83 Ea his father begat him,
84 Damkina his mother bore him.
85 He sucked the breasts of goddesses,
86 A nurse reared him and filled him with terror.
87 His figure was well developed, the glance of his eyes was dazzling,
88 His growth was manly, he was mighty from the beginning.
89 Anu, his father's begetter, saw him,
90 He exulted and smiled; his heart filled with joy.
91 Anu rendered him perfect: his divinity was remarkable,
92 And he became very lofty, excelling them in his attributes.
93 His members were incomprehensibly wonderful,
94 Incapable of being grasped with the mind, hard even to look on.
95 Four were his eyes, four his ears,
96 Flame shot forth as he moved his lips.
97 His four ears grew large,
93 And his eyes likewise took in everything.
99 His figure was lofty and superior in comparison with the gods,
100 His limbs were surpassing, his nature was superior.
101 'Mari-utu, Mari-utu,
102 The Son, the Sun-god, the Sun-god of the gods.'
103 He was clothed with the aura of the Ten Gods, so exalted was his strength,
104 The Fifty Dreads were loaded upon him.
105 Anu formed and gave birth to the four winds,
106 He delivered them to him, "My son, let them whirl!"
107 He formed dust and set a hurricane to drive it,
108 He made a wave to bring consternation on Tia-mat.
109 Tia-mat was confounded; day and night she was frantic.
110 The gods took no rest, they . . . . . . .
111 In their minds they plotted evil,
112 And addressed their mother Tia-mat,
113 "When Apsû, your spouse, was killed,
114 You did not go at his side, but sat quietly.
115 The four dreadful winds have been fashioned
116 To throw you into confusion, and we cannot sleep.
117 You gave no thought to Apsû, your spouse,
113 Nor to Mummu, who is a prisoner. Now you sit alone.
119 Henceforth you will be in frantic consternation!
120 And as for us, who cannot rest, you do not love us!
121 Consider our burden, our eyes are hollow.
122 Break the immovable yoke that we may sleep.
123 Make battle, avenge them!
124 [ . . ] . . . . reduce to nothingness!
125 Tia-mat heard, the speech pleased her,
126 (She said,) "Let us make demons, [as you] have advised."
127 The gods assembled within her.
128 They conceived [evil] against the gods their begetters.
129 They . . . . . and took the side of Tia-mat,
130 Fiercely plotting, unresting by night and day,
131 Lusting for battle, raging, storming,
132 They set up a host to bring about conflict.
133 Mother H(ubur, who forms everything,
134 Supplied irresistible weapons, and gave birth to giant serpents.
135 They had sharp teeth, they were merciless . . . .
136 With poison instead of blood she filled their bodies.
137 She clothed the fearful monsters with dread,
138 She loaded them with an aura and made them godlike.
139 (She said,) "Let their onlooker feebly perish,
140 May they constantly leap forward and never retire."
141 She created the Hydra, the Dragon, the Hairy Hero
142 The Great Demon, the Savage Dog, and the Scorpion-man,
143 Fierce demons, the Fish-man, and the Bull-man,
144 Carriers of merciless weapons, fearless in the face of battle.
145 Her commands were tremendous, not to be resisted.
146 Altogether she made eleven of that kind.
147 Among the gods, her sons, whom she constituted her host,
148 She exalted Qingu, and magnified him among them.
149 The leadership of the army, the direction of the host,
150 The bearing of weapons, campaigning, the mobilization of conflict,
151 The chief executive power of battle, supreme command,
152 She entrusted to him and set him on a throne,
153 "I have cast the spell for you and exalted you in the host of the gods,
154 I have delivered to you the rule of all the gods.
155 You are indeed exalted, my spouse, you are renowned,
156 Let your commands prevail over all the Anunnaki."
157 She gave him the Tablet of Destinies and fastened it to his breast,
158 (Saying) "Your order may not be changed; let the utterance of your mouth be firm."
159 After Qingu was elevated and had acquired the power of Anuship,
160 He decreed the destinies for the gods, her sons:
161 "May the utterance of your mouths subdue the fire-god,
162 May your poison by its accumulation put down aggression."
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#6
Aug 1, 2015, 04:35 PM
Great news!
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#7
Aug 1, 2015, 05:57 PM
This is great news! Hopefully Ebola can be ridden of altogether in a few years time.
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#8
Aug 1, 2015, 05:58 PM
This is great news, soon enough we may be able to eradicate Ebola.
Regards

Echo
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#9
Aug 1, 2015, 07:46 PM
Fantastic hopefully it will be possible to eradicate it
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#10
Aug 1, 2015, 08:36 PM
Conspiracy theory inbound:

The current ebola is just a modified strand of the previously eradicated version. This new strand was planted in regions of countries that are underdeveloped in medicinal technology. Majority developed countries turn to the affected governments and offer assistance in return for a reward (typically another 100 years of mineral rights for the UK, that didn't seem suspicious, did it?).
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“I expect to die in bed, my successor will die in prison and his successor will die a martyr in the public square. His successor will pick up the shards of a ruined society and slowly help rebuild civilisation, as the Church has done so often in human history”  ~ His Eminence, Cardinal Francis George
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#11
Aug 2, 2015, 05:55 AM
Woo for science!
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#12
Sep 30, 2018, 10:30 PM
Damn, that's pretty cool @Welker
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#13
Sep 30, 2018, 10:39 PM
(Sep 30, 2018, 10:30 PM)Markus Wrote: Damn, that's pretty cool @Welker

holy son of a necropost lmfao
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rockin the new sig gimme rep
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