Aug 1, 2015, 02:04 PM
To test how well the vaccine protected people, the cluster outbreaks were randomly assigned either to receive the vaccine immediately or three weeks after Ebola was confirmed. Among the 2,014 people vaccinated immediately, there were no cases of Ebola from 10 days after vaccination – allowing time for immunity to develop – according to the results published online in the Lancet medical journal. In the clusters with delayed vaccination, there were 16 cases out of 2,380.
In another precedent-breaker, the trial was sponsored by the World Health Organisation because “nobody wanted to step into this role so we took the risk”, said assistant director-general, Dr Marie-Paule Kieny.
Funding came from the Wellcome Trust and other partners, including the governments of Norway and Canada. Others involved included Médecins sans Frontières, whose volunteer doctors were on the front line, and the London School of Hygiene and Tropical Medicine. About 90% of the trial staff were from Guinea, a country where no clinical research had been carried out before. The vaccine is made by Merck.
Kieny said: “We believe that the world is on the verge of an efficacious Ebola vaccine.”
The trial will continue, but without randomisation, which means that in Guinea, where there have been 3,786 cases and 2,520 confirmed deaths, every contact of a person who develops Ebola – and their contacts – will be offered it. Work in Gabon has now established that the vaccine is safe for children and adolescents, so they will be offered it, too.
Ebola in Sierra Leone: 'Remind people not to forget about us, the survivors'
In terms of vaccines, which are usually trialled in hundreds of thousands of people, Kierny said the numbers were small but highly promising. It is likely when larger numbers are collected that efficacy will be between 75% and 100%.
The future of two other potential Ebola vaccines, one from GlaxoSmithKline and the other from Johnson & Johnson, is now in question, because there are too few cases of Ebola for their trials to be completed.
The authors of the research said the ring design made it “logistically feasible” to conduct trials even in poor countries in the middle of a fading epidemic and it was a promising strategy for the future.
“This trial dared to use a highly innovative and pragmatic design, which allowed the team in Guinea to assess this vaccine in the middle of an epidemic,” said Jeremy Farrar, director of the Wellcome Trust and one of the world’s leading experts on infectious disease. “It is a remarkable result which shows the power of equitable international partnerships and flexibility.
“Our hope is that this vaccine will now help bring this epidemic to an end and be available for the inevitable future Ebola epidemics. This partnership also shows that such critical work is possible in the midst of a terrible epidemic. It should change how the world responds to such emerging infectious disease threats.”
UN special envoy says Ebola flare-ups could continue for some time
John-Arne Røttingen, the head of infectious disease control at the Norwegian Institute of Public Health and chair of the trial’s steering group, said it had been a race against time in the most challenging circumstances.
“We are really pleased with the interim results,” he said. “It is really important to add the vaccine to the traditional hygiene measures we have used in the response so far. I believe this will be an important contribution to getting down to zero cases.”
Médecins sans Frontières said it was keen for the vaccine to be used in Sierra Leone and Liberia, where there were still cases.
Bertrand Draguez, MSF’s medical director, said: “In parallel with the ring vaccination we are also conducting a trial of the same vaccine on front-line workers. These people have worked tirelessly and put their lives at risk every day to take care of sick people. If the vaccine is effective, then we are already protecting them from the virus.
“With such high efficacy, all affected countries should immediately start and multiply ring vaccinations to break chains of transmission and vaccinate all front-line workers to protect them.”
WHO incapable of reacting to crises such as Ebola, says report
Margaret Chan, the director general of of the WHO, said the vaccine trial’s success was a promising development. “The credit goes to the Guinean government, the people living in the communities and our partners in this project.”
The British government contributed £1m of the trial funding and has said it will increase that amount to help allow the testing to continue.
“Ebola has claimed thousands of lives and devastated communities across west Africa,” the international development secretary, Justine Greening, said. “The results of these UK-backed vaccine trials are hugely promising and represent a significant breakthrough in our battle against this deadly disease. The vaccine offers hope for a future where we never have to face an Ebola epidemic like this again.”
Trial data will now go to regulatory agencies in the hope of getting a licence for the vaccine that will allow it to be stockpiled for future Ebola epidemics. It is likely to be used only for people at risk in outbreaks and not given to whole populations.
The rVSV-ZEBOV vaccine is sometimes known as the Canadian vaccine as it was originally developed by the Public Health Agency of Canada before being sold to Merck to conclude the testing.
I've never done a news thread but it was empty and it looked lonely.. ???
In another precedent-breaker, the trial was sponsored by the World Health Organisation because “nobody wanted to step into this role so we took the risk”, said assistant director-general, Dr Marie-Paule Kieny.
Funding came from the Wellcome Trust and other partners, including the governments of Norway and Canada. Others involved included Médecins sans Frontières, whose volunteer doctors were on the front line, and the London School of Hygiene and Tropical Medicine. About 90% of the trial staff were from Guinea, a country where no clinical research had been carried out before. The vaccine is made by Merck.
Kieny said: “We believe that the world is on the verge of an efficacious Ebola vaccine.”
The trial will continue, but without randomisation, which means that in Guinea, where there have been 3,786 cases and 2,520 confirmed deaths, every contact of a person who develops Ebola – and their contacts – will be offered it. Work in Gabon has now established that the vaccine is safe for children and adolescents, so they will be offered it, too.
Ebola in Sierra Leone: 'Remind people not to forget about us, the survivors'
In terms of vaccines, which are usually trialled in hundreds of thousands of people, Kierny said the numbers were small but highly promising. It is likely when larger numbers are collected that efficacy will be between 75% and 100%.
The future of two other potential Ebola vaccines, one from GlaxoSmithKline and the other from Johnson & Johnson, is now in question, because there are too few cases of Ebola for their trials to be completed.
The authors of the research said the ring design made it “logistically feasible” to conduct trials even in poor countries in the middle of a fading epidemic and it was a promising strategy for the future.
“This trial dared to use a highly innovative and pragmatic design, which allowed the team in Guinea to assess this vaccine in the middle of an epidemic,” said Jeremy Farrar, director of the Wellcome Trust and one of the world’s leading experts on infectious disease. “It is a remarkable result which shows the power of equitable international partnerships and flexibility.
“Our hope is that this vaccine will now help bring this epidemic to an end and be available for the inevitable future Ebola epidemics. This partnership also shows that such critical work is possible in the midst of a terrible epidemic. It should change how the world responds to such emerging infectious disease threats.”
UN special envoy says Ebola flare-ups could continue for some time
John-Arne Røttingen, the head of infectious disease control at the Norwegian Institute of Public Health and chair of the trial’s steering group, said it had been a race against time in the most challenging circumstances.
“We are really pleased with the interim results,” he said. “It is really important to add the vaccine to the traditional hygiene measures we have used in the response so far. I believe this will be an important contribution to getting down to zero cases.”
Médecins sans Frontières said it was keen for the vaccine to be used in Sierra Leone and Liberia, where there were still cases.
Bertrand Draguez, MSF’s medical director, said: “In parallel with the ring vaccination we are also conducting a trial of the same vaccine on front-line workers. These people have worked tirelessly and put their lives at risk every day to take care of sick people. If the vaccine is effective, then we are already protecting them from the virus.
“With such high efficacy, all affected countries should immediately start and multiply ring vaccinations to break chains of transmission and vaccinate all front-line workers to protect them.”
WHO incapable of reacting to crises such as Ebola, says report
Margaret Chan, the director general of of the WHO, said the vaccine trial’s success was a promising development. “The credit goes to the Guinean government, the people living in the communities and our partners in this project.”
The British government contributed £1m of the trial funding and has said it will increase that amount to help allow the testing to continue.
“Ebola has claimed thousands of lives and devastated communities across west Africa,” the international development secretary, Justine Greening, said. “The results of these UK-backed vaccine trials are hugely promising and represent a significant breakthrough in our battle against this deadly disease. The vaccine offers hope for a future where we never have to face an Ebola epidemic like this again.”
Trial data will now go to regulatory agencies in the hope of getting a licence for the vaccine that will allow it to be stockpiled for future Ebola epidemics. It is likely to be used only for people at risk in outbreaks and not given to whole populations.
The rVSV-ZEBOV vaccine is sometimes known as the Canadian vaccine as it was originally developed by the Public Health Agency of Canada before being sold to Merck to conclude the testing.
I've never done a news thread but it was empty and it looked lonely.. ???